City are on course to win a third consecutive Premier League title this season after reeling in Arsenal, but the elusive Champions League is still what drives the club.
This is a third straight year in which Pep Guardiola's side have reached at least the semi-finals, facing Real Madrid again after late goals cost them the tie this time last year.
Here's a look at the starting XI Guardiola could pick as City head to Spain.
Man City predicted lineup vs Real Madrid
GK: Ederson - There is no doubting who starts in goal for one of the biggest games of the season.
CB: Kyle Walker - Speed and strength will be invaluable assets in this hybrid role, especially as the primary defender who will be tasked with stopping Vinicius Junior.
CB: Ruben Dias - Set to return to the defence after being rested against Leeds.
CB: Manuel Akanji - Injury to Nathan Ake presents an opportunity for Akanji to start instead.
DM: John Stones - Has made this role his own over the past month or so and played it well in both quarter-final legs against Bayern Munich.
DM: Rodri - The Spaniard will be crucial to controlling the game and stopping Real playing.
RM: Bernardo Silva - Remains an invaluable part of Guardiola's strongest side even if his preference continues to be a summer transfer elsewhere.
AM: Kevin De Bruyne - The relationship he has developed with Erling Haaland this season will be vital to City's prosperity over the course of this tie.
AM: Ilkay Gunodgan - The German could be playing against Real Madrid regularly for the next couple of years if Barcelona get their way this summer.
LM: Jack Grealish - Firmly trusted by Guardiola this season and has started nine out of 10 Champions League games so far. Rested at the weekend and should be fresh.
ST: Erling Haaland - Already on 51 goals for the season. How many could he get against a Real defence without its best centre-back.
